2011-07-23-世界卫生组织-WHO_HPV_LabNet_-_Newsletter_08_13页_829kb

WHO HPV LabNet Newsletter Summary (No.8, 2011)

Key Determinants of LabNet Activities

1. Supporting HPV Vaccine Introduction: Ensuring quality, safety and efficacy standards for HPV vaccines developed for cervical cancer prevention.

2. International Reference System: Creating a global reference laboratory network to support standardized laboratory testing.

3. Enabling Environment: Providing guidelines, standards, and technical support for HPV monitoring globally.

Core Activities and Achievements

Development of International Standards and Guidelines

• Development of WHO guidelines and standards for HPV vaccines, tests and assays was formalized following expert consultations.
• Establishment of two WHO HPV Global Reference Laboratories (GRLs) and eight Regional Reference Laboratories (RRLs) in 2006.
• Creation of international standards (IS) for specific HPV types (16 and 18 DNA, and serum antibodies) to harmonize global testing.

Technical Assistance and Capacity Building

• Extensive training programs conducted with technical support to national laboratories in developing countries were implemented.
• Technology transfer initiated via workshops and proficiency studies improved lab proficiency regarding assays like the PGMY-RBH DNA genotyping test.
• Regular proficiency testing enabled global comparison of HPV testing results and pinpointed required improvements.

Harmonization and Standardization of HPV Assays

• Intensive collaborative studies established criteria for sensitive and specific HPV DNA genotyping assays and serology tests.
• Key tests approved for inclusion in the WHO HPV Laboratory Manual* included VLP-ELISA and the RBH DNA genotyping assay.

Publications and Networking Activities

• Significant research outputs led to publications in journals covering HPV antibody measurements, DNA detection, and vaccine development contributions.
• The HPV LabNet manual was published, offering practical guidance for global labs involved in cervical cancer monitoring and vaccination.

Meeting Reports and Upcoming Events

• A workshop in Argentina coordinated by the GRL enhanced the capabilities of local labs through training and networking.
• The newsletter highlights two upcoming conferences related to HPV in 2011 - a symposium in Berlin and a symposium and clinical workshop in Bern.

Web Links Provided

• WHO Global HPV Information Centre
• WHO/CCLD
• NIBSC
• IARC
• HPV research organizations

Note: This summary presents the key findings, activities, and developments described in the report, focusing on the operational aspects of the WHO HPV LabNet from July 2011.