2024-09-27-世界卫生组织-Multi-country_outbreak_of_mpox,_External_situation_report_38_-_28_September_2024_14页_1mb

Mpox Multi-country External Situation Report Analysis

Key Overview

This report updates the mpox epidemiological situation as of 22 September 2024, covering Africa and global data. Key figures include 6603 confirmed mpox cases and 32 deaths in Africa, and 106,310 cases and 234 deaths globally from 2022 to August 2024. The Democratic Republic of the Congo (DRC) accounts for most cases, with 5621 confirmed cases and 25 deaths in 2024, driven by clade Ib MPXV in provinces like South Kivu.

Epidemiological Highlights

• In Africa, mpox cases are rising, with all affected countries reporting new cases in the last six weeks. Guinea reported its first case in September 2024. Testing challenges persist, such as low positivity and delays in reporting.
• Burundi saw a 71% district involvement with high pediatric cases (30%), and improved testing rates.
• DRC provinces like Equateur and South Kivu show varying CFRs, with South Kivu having a low CFR of 0.5% due to adult predominance.

Global Operational Updates

WHO activities focus on emergency coordination, surveillance, community protection, care, and countermeasures. Recent updates include:

• EMA recommending vaccine MVA-BN extension to adolescents.
• WHO promoting research on diagnostics, therapeutics, and vaccination strategies to control outbreaks.

Special Focus on Research Roadmap

A coordinated research plan prioritizes 10 steps, such as gathering transmission data, developing rapid diagnostics, and defining regulatory pathways for medical countermeasures, emphasizing collaboration with affected countries.

Resources and Links

WHO provides various guidelines, tools, and fact sheets on mpox surveillance, clinical management, vaccination, and resources for outbreak response, including genomic epidemiology and training modules.