2025-05-11-世界卫生组织-INN_Stem_Book_Addendum_202503-2025_4页_65kb

报告摘要

Addendum to "The use of stems..." (INN 2024)
This document is a cumulative list of new INN stems selected by the INN Expert Group since the 2024 publication.

New Stems Added

By Therapeutic Area/Target

ALK inhibitors (c category):
alectinib (108), brigatinib (113), ceritinib (109), crizotinib (103), ensartinib (115), nasartinib (115).
Related compounds: alibk (132), envonalkib (126), ficonalkib (128), neladalkib (130), iruplinalkib (126), zotizalkib (128).
AMPA Receptor Modulators:
farampator (92), mibampator (103), osavampator (129), pesampator (126), tulrampator (116).
CCR Antagonists:
ilacirnon (123), lazucirnon (123), tivumecirnon (128), vercirnon (107), zelnecirnon (130).
Menin Interaction Inhibitors (cancer):
balomenib (132), bleximenib (129), emilumenib (129), enzomenib (130), icovamenib (130), revumenib (126), ziftomenib (127).
Nucleoside Analogues (antivirals/antineoplastics):
adenosine phosphate (14), alanosine (48), ateganosine (130), didanosine (64), fosdesdenosine (130), inosine (42), lodenosine (78).
PTP Inhibitors:
batoprotafib (127), ertiprotafib (87), migoprotafib (128), osunprotafib (129), razuprotafib (116), tegeprotafib (129), vociprotafib (127).
RORγ Antagonists:
bevurogant (125), cedirogant (123), izumerogant (128), retezorogant (126), vimirogant (120).
Aldosterone/Cortisol Synthesis Inhibitors (drostat):
osilodrostat (110), baxdrostat (125), dexfadrostat (126), lorundrostat (127), vicadrostat (130).
Oncolytic Viruses (turev):
Canerpaturev (117), gebasaxturev (126), lerapolturev (125), lino...
Enadenotucirev (111).
Protein Vaccines:
Covatein (coronavirus vaccines).
Antivirals (vir / trelvir):
Abimtrelvir (126), ensitrelvir (126), nirmatrelvir (126), etc.

Stem Definitions Amendments

Cyanine: Repurposed from "indocyanine fluorescence dye" to "cyanine dyes and their derivatives, diagnostic imaging agents".
Phylline: Added as a new category under "N-alkylated xanthine derivatives".
Sematilide (−ilide): Updated description.
Kalim: Updated to "potassium channel activators, antihypertensives".
Kinra: Added under "interleukin receptor antagonists and interleukin inhibitors".
Onidine: Repurposed from "antihypertensives, clonidine derivatives" to "α adrenoreceptor agonists".

Additional Notes

Monoclonal Antibody Naming Rule:
A new standard for monoclonal antibodies adopted post-73rd INN Consultation; available here.

Note: Abbreviations like -mab are now under -gromab for skeletal muscle factors and -ki- for interleukin-related antibodies. For example, -mab prefixes "migalastat" and similar derivatives are now defined accordingly.

Infix updates: -gromab, -ki- for specific targets.