2012-12-30-世界卫生组织-INN_Stem_Book_2013_192页_878kb
报告摘要
Summary of WHO INN Stem System
The World Health Organization's International Nonproprietary Name (INN) system uses stems (common suffixes) to categorize the pharmacological activity of drug substances. These stems help distinguish between different classes of drugs with similar chemical structures or mechanisms of action.
Key Points
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Stem System:
- Stems define pharmacologically related groups categorized by therapeutic action, origin (natural/biological vs. synthetic), and chemical classification.
- The stem is typically placed at the end of the name (except where space is tight).
- The system aims for clarity, uniqueness, avoid sounds and spelling likely to confuse with common terms, and length to be not inconveniently long.
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Classification:
- INNs are grouped into codes like A (CNS Depressants), B (Psychopharmacologics), etc., corresponding to major therapeutic classes.
- Subcategories under each classification (e.g., A100, A200) reflect specific activities within the primary class.
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Application:
- Stems are used globally on drug labels, regulatory documents, and scientific literature to ensure clear identification and safe use.
- INNs are freely usable by WHO Member States, preventing trademark registration and ensuring nonproprietary access.
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Guiding Principles:
- Generic names should be distinctive, not long, not easily confused with common names or trademarks.
- New groups should be linked with appropriate stems. Existing systems use established stems for related substances.
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Purpose:
- Facilitates global public health by ensuring unique identification of pharmaceutical substances.
- Eliminates the need for multiple proprietary names or national variations.
- Supports clear communication, prescription, and dispensing among health professionals worldwide.
The INN stem system provides a structured and universally accepted way to name new drug substances, enhancing safety and efficiency in global healthcare.
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