2021-09-28-世界卫生组织-Terms_of_Reference_for_the_Technical_Advisory_Group_on_COVID-19_Vaccine_Composition_5页_156kb

报告摘要

Summary of TAG-CO-VAC Terms of Reference

Purpose

The Technical Advisory Group on COVID-19 Vaccine Composition (TAG-CO-VAC) was established to advise the World Health Organization (WHO) on COVID-19 vaccine composition adjustments. This is to address the impact of SARS-CoV-2 variants of concern (VOCs) on vaccines, ensuring continued efficacy, safety, and equitable access globally.

Key Functions

TAG-CO-VAC has three main advisory roles:

Recommend assessment methods for evaluating how VOCs affect vaccines.
Interpret available evidence on VOC impacts, including vaccine effectiveness and safety.
Suggest specific adaptations for each vaccine platform to maintain WHO-recommended protection levels against VOCs.

Composition

Up to 20 members with expertise in virology, immunology, clinical trials, manufacturing, and other relevant disciplines.
Members are appointed by WHO for one-year terms and can be reappointed.
Appointment considers technical expertise, geographical representation, and gender balance to avoid conflicts of interest.
No remuneration, but travel expenses covered for in-person meetings. All members must disclose conflicts of interest and adhere to strict independence and impartiality standards.

Operation

Regular monthly meetings, which can be held virtually or in person, allowing for open or closed sessions based on the topic.
Decisions are made by consensus; if consensus is unattainable, minority opinions are included in reports.
WHO provides secretariat support, including documents and administrative aid.
Collaborates with other WHO groups like SAGE and TAG-VE for coordinated responses and research on vaccine effectiveness and surveillance.

Overall Scope

TAG-CO-VAC supports WHO's global efforts to monitor SARS-CoV-2 variants, with a focus on evidence-based recommendations and maintaining public health strategies post-pandemic.

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