2023-10-02-世界卫生组织-A_H3N2_variant_-_Southern_hemisphere_2024_2页_229kb

报告摘要

Summary of Variant Influenza A(H3N2) Candidate Vaccine Viruses and Potency Testing Reagents Status

Overview: The report details the status of variant influenza A(H3N2) candidate vaccine viruses (CVVs) and reference reagents.
Assessment: Antigenic and genetic analyses are performed by WHO GISRS Collaborating Centres (CCs). CVV status on the table indicates they have passed two-way HI tests. National/regional authorities approve vaccine composition/formulation.
Current CVVs:
- A/Minnesota/11/2010 NYMC X-203: Conventional reassortant. Wild type virus used: A/Minnesota/11/2010 (WHO CCs). Source institute: NYMC, USA. Operational status: Available.
- A/Minnesota/11/2010 NYMC X-203A: Conventional reassortant. Wild type virus used: A/Minnesota/11/2010 (WHO CCs). Source institute: NYMC, USA. Operational status: Available.
- A/Indiana/10/2011 NYMC X-213: Conventional reassortant. Wild type virus used: A/Indiana/10/2011 (WHO CCs). Source institute: NYMC, USA. Operational status: Available.
- A/Ohio/28/2016 ID CDC-RG55C: Conventional reassortant developed using reverse genetics (CDC-RG). Wild type virus used: A/Ohio/28/2016. Source institute: CDC, USA. Operational status: Available.
Preparations/Outstanding CVVs:
- A/Ohio/28/2016 Conventional reassortant: Source institute: MHRA, UK. Operational status: Pending.
- A/Ohio/13/2017-like Reassortant: Source institute: CDC, USA (reverse genetics). Operational status: Pending.
- A/swine/Iowa/23TOSU0850/2023: Developed via reverse genetics (CDC source). Operational status: Pending.
Reference Antigens/Lot Information:
- Specific CVV parent viruses available with specified HA unitage.
- Availability of parent virus lots and sheep antisera subject to Institutional justification and potential restrictions.
Contact: Orders/information requests for CVVs should be directed to CDC, MHRA, NYMC, or WHO CCs. General enquiries: gisrs-whohq@who.int.