Thermo+Fisher+膳食补充剂和植物天然产品-英-90页_8mb

Summary of Dietary Supplements and Botanical Natural Products Analysis

This document focuses on the chromatographic analysis of dietary supplements and botanical natural products using High-Performance Liquid Chromatography (HPLC), specifically employing UV-Vis absorbance and Charged Aerosol Detection (CAD) as detection methods. The content outlines market growth driven by consumer health concerns and regulatory trends.

Key Themes and Methodologies

• Analysis Techniques: Emphasizes the use of HPLC to measure various compounds, including vitamins, botanicals, steroids, saponins, and phenolic compounds. CAD detectors are highlighted for their universality, sensitivity on non-chromophoric compounds, and compatibility with data analysis tools like Principal Component Analysis (PCA) for authentication.
• Instrumentation & Separation: Covers advancements in HPLC systems, columns (e.g., C18, Accucore, Polar Embedded), and sample preparation tools like Accelerated Solvent Extractors (ASE), enabling efficient handling of complex matrices.
• Challenges Addressed:
  • Authentication and quality control through untargeted and targeted metabolomics to counteract adulteration and ensure product purity.
  • Overcoming limitations in standard quantification, such as lacking authentic standards, by leveraging CAD for reliable, structure-independent measurements.
• Applications: Includes standardized methods for specific compounds (e.g., artemisinin, ginsenosides, catechins, vitamins) and dietary supplements, ensuring safety and efficacy in regulated environments.

Regulatory and Market Context

• References the global market growth, nutraceutical trends, and the role of chromatography in regulatory monitoring.
• Stressing alignment with pharmacopeias, FDA safety guidelines, and authenticity studies in traditional medicines like Ayurveda and Chinese medicine.

Conclusion

The combined approaches of chromatography, advanced detectors, and chemometric analyses provide a comprehensive framework for evaluating, authenticating, and monitoring botanical-based products for consumer safety and regulatory compliance.