2015-10-24-世界卫生组织-WHO_BS_2015.2272_Requests_to_initiate_new_WHO_reference_material_projects_for_vaccines_and_related_substances_22页_352kb

WHO requests for new reference material projects focus on vaccines and related substances to standardize assays and ensure quality control. The proposals include developing international standards for antibodies against typhoid, invasive nontyphoidal Salmonella, Shigella, and other pathogens by NIBSC proposer Sjoerd Rijpkema. Common themes involve public health importance, such as reducing mortality in developing countries and enabling vaccine immunogenicity assessments through collaborative studies with labs worldwide. These standards aim to calibrate assays, address regulatory needs, and are subject to ECBS endorsement or modification. Funding requirements, like contributions from BMGF or Wellcome Trust, are specified, with a tight deadline for comments. Each project underscores the need for measurements with low uncertainty to support global health initiatives.