2022-06-28-世界卫生组织-INN_74th_Executive_Summary_13页_340kb

报告摘要

Welcome & Election: Chair Prof. Sarel Malan was elected unopposed. Dr. Clive Ondari (HPS Director) welcomed participants, announced a hybrid format, and noted a shift back to in-person meetings if COVID allows.
Requests Processed: Over 250 requests (220 new, 19 COVID-19 related) were discussed. 240 names selected, 4 rejected, 6 deferred.
Biosimilar Focus: Biological Qualifier (BQ) re-examined; a new concept note proposed post-management review after 2016 stalemate.
Virtual Sessions: Virtual attendance remains optional due to accessibility.

Antibodies: INN Group explores AbML, a text-based language for complex multi-specific antibodies. A tool to generate/syntax-check names is under development.
Peptide Harmonization: INN uses -motide, USAN uses -IMUT (for immunomodulators). No immediate common ground; USAN allows peptides + adjuvants in names, complicating INN assignment.
Viral Vector Vaccines: Debate to name vaccines differently (e.g., one-word suffixes like -vavec) vs. re-naming gene-therapy schemes. Majority agree on a dedicated vaccine nomenclature.

Biological Qualifier (BQ): A 4-letter code (e.g., BQxxxx) is proposed instead of full names. Bumper note drafted; feedback requested. Note: Not adopted due to past lack of member-state consensus.
Gene Therapy: Substances use two-word INN names (e.g., ibacovtogene lomadenovec for COVID adenovirus vaccine). Originally rejected one-word requests.
Vaccine Specificity: Suffix -vavec proposed for viral vectors to replace generic gene-therapy nomenclature.

USAN: Stem list approved/updated; 61 names/INNs adopted in 2022.
School of INN: Courses expanded; new biennial executive programme discussions.
Regulatory Agencies: PMDA (Japan), TGA (Australia), ANVISA (Brazil) detail recent INN contributions.
WHO Drug Information: INN highlights message proposed.

Chair (Malan) & Head (Balocco) thanked participants for input. Next Consultation in Oct. 2022 announced.
Topic suggestions for future meetings encouraged.

展开完整摘要