2007-06-08-世界卫生组织-INN_Proposed_List_97_58页_485kb

Summary of Proposed International Nonproprietary Names (INN) for Pharmaceutical Substances

Core Content

The document provides information about the International Nonproprietary Names (INN) for pharmaceutical substances, which are proposed by the World Health Organization (WHO). These names are used to identify substances in a standardized way across countries, ensuring clarity and consistency in medical and pharmaceutical contexts. The document includes a list of proposed names, their chemical descriptions, and related properties and uses, along with molecular formulas and CAS registry numbers. It also outlines the process for submitting comments or objections to these proposed names.

Main Points

• INN Purpose: INNs are standardized names for pharmaceutical substances to avoid confusion and ensure global consistency.
• Provisional Nature: Proposed INNs are not final and do not imply any recommendation for medical use. They are for informational purposes only.
• Comment Period: Comments or formal objections can be submitted to the WHO INN Programme within four months of the publication date of the list.
• Publication Date: The publication date for List 97 is June 25, 2007, with the deadline for comments set for October 31, 2007.
• Language Variations: The names are listed in multiple languages, including Latin, English, French, Spanish, and Portuguese.
• Chemical Descriptions: Each proposed name includes a chemical name, molecular formula, and CAS registry number, providing detailed chemical information.
• Properties and Uses: The substances are associated with specific actions and uses, such as antidiabetic, antiviral, antispasmodic, and antineoplastic.

Key Information

Proposed INN: List 97

• Comment Deadline: October 31, 2007.
• Publication Date: June 25, 2007.
• Available Format: The list is available only in CD-ROM format.

Examples of Proposed INNs

• brivanib alaninate

  • Chemical Name: (2R)-1-(4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo [2,1-f][1,2,4]triazin-6-yl)oxy)propan-2-yl L-alaninate
  • Action and Use: Angiogenesis inhibitor
  • Molecular Formula: $\mathrm{C_{22}H_{24}FN_5O_4}$
  • CAS Registry Number: 649735-63-7

• albiglutide

  • Chemical Name: ([8-glycine]human glucagon-like peptide 1-(7-36)-peptidyl)(human serum albumin (585 residues))
  • Action and Use: Antidiabetic
  • Molecular Formula: C3232H5032N864O979S41
  • CAS Registry Number: 782500-75-8

• apremilast

  • Chemical Name: N-[2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methanesulfonyl)ethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]acetamide
  • Action and Use: Antiviral
  • Molecular Formula: $\mathrm{C_{30}H_{32}N_4O_7S}$
  • CAS Registry Number: 863031-24-7

• carfilzomib

  • Chemical Name: 4-((4-carboxybutyl)[2-(2-{[4-(2-phenylethyl)phenyl]methoxy}phenyl)= ethyl]amino)methyl)benzoic acid
  • Action and Use: Guanylate cyclase activator
  • Molecular Formula: $\mathrm{C_{36}H_{39}NO_5}$
  • CAS Registry Number: 329773-35-5

• dapagliflozin

  • Chemical Name: (1S)-1,5-anhydro-1-C-{4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl}-D-glucitol
  • Action and Use: Antidiabetic
  • Molecular Formula: $\mathrm{C_{21}H_{25}ClO_6}$
  • CAS Registry Number: 461432-26-8

• elvitegravir

  • Chemical Name: 6-[(3-chloro-2-fluorophenyl)methyl]-1-[(2S)-1-hydroxy-3-methylbutan-2-yl)-7-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
  • Action and Use: Antiviral
  • Molecular Formula: $\mathrm{C_{30}H_{32}N_4O_7S}$
  • CAS Registry Number: 863031-24-7

• azoximer bromide

  • Chemical Name: poly{[1-(carboxymethyl)piperazin-1-ium-1,4-diyl bromide]ethylene-co-[(piperazin-1,4-diyl 1-oxide)ethylene]}
  • Action and Use: Immunomodulator
  • Molecular Formula: $\left[[\mathrm{C}8\mathrm{H}{15}\mathrm{BrN}_2\mathrm{O}_2\right]_x[\mathrm{C}6\mathrm{H}{12}\mathrm{N}_2\mathrm{O}]_y]_n$
  • CAS Registry Number: 892497-01-7

• contusugene ladenovec

  • Description: A replication-restricted adenovirus vector (type 5), E1 deleted, partial E3 deletion, containing a wild-type p53 gene under the control of a cytomegalovirus promoter.
  • Action and Use: Induces cell growth arrest and apoptosis.
  • CAS Registry Number: 600735-73-7

• anamorelin

  • Chemical Name: (3R)-3-benzyl-N,N',N'-trimethyl-1-(2-methylalanyl-D-tryptophyl)piperidine-3-carbohydrazide
  • Action and Use: Growth hormone-releasing factor
  • Molecular Formula: C23H23CIFNO5
  • CAS Registry Number: 697761-98-1

Conclusion

The document outlines the process for reviewing proposed INNs and provides detailed information on the chemical composition, potential uses, and molecular data for various pharmaceutical substances. It emphasizes that these names are not final and are subject to public comment, with the final decision on their adoption being made by the WHO. The inclusion of names in the Cumulative List No. 12, 2007 is not guaranteed and depends on the outcome of the review process.