2021-06-06-世界卫生组织-WGS_for_surveillance_of antimicrobial_resistance_–_Feedback_from_countries_–_Daniel_Marcano_Zamora_10页_1mb

Document Overview: The document "WGS for surveillance of antimicrobial resistance" reviews benefits and limitations of WGS technologies for AMR surveillance, analyzes WGS application for single bacterial pathogens, and outlines laboratory requirements for establishing or upgrading WGS facilities, considering various lab levels.

Country Feedback Summary: 57 countries responded to the survey. 91% of countries found the document provides clear guidance for AMR surveillance, and 84% apply molecular methods including WGS to their AMR surveillance systems.

Current Implementation: 32% of countries report using WGS in AMR surveillance, driven by demands for a dedicated budget, long-term planning, data sharing procedures, and standardized workflows. Other requirements include clear national coordinators and data management strategies.

Barriers to Application: 65% of countries do not apply WGS, with common reasons being a need for WHO support, financial constraints, lack of technical training, equipment, and reagents. Countries in this category often noted that WGS application is under consideration.

Database Recommendations: Respondents were asked about database type for genomic AMR data storage. 42% favored public-access databases, which allow controlled access for specific users, addressing issues of data confidentiality while facilitating collaboration.

Overall Feedback: Feedback from countries was predominantly positive, with all comments being constructive, highlighting practical challenges to wider WGS adoption and suggesting specific support needs, illustrating variations based on regional resources.