2004-12-08-世界卫生组织-INN_Proposed_List_92_43页_260kb

报告摘要

Summary of Proposed International Nonproprietary Names for Pharmaceutical Substances (INN)

Core Content

The document outlines the process and lists of Proposed International Nonproprietary Names (INNs) and Recommended INNs for pharmaceutical substances, as maintained by the World Health Organization (WHO). These names are used to standardize the naming of drugs across different countries to facilitate identification and communication in global healthcare. The document includes a list of Proposed INNs (List 92), along with their chemical names, molecular formulas, CAS registry numbers, and associated functions or uses.

Key Information

Proposed INNs (List 92) are under consideration by the WHO for inclusion in the official list of INNs.
These names are not officially recommended for use in medicine or pharmacy.
The Cumulative List No. 10, 2002 contains both Proposed and Recommended INNs, available only on CD-ROM.
The statements about the action and use of the substances are based on manufacturer information and are not verified or endorsed by WHO.
These descriptors are provisional and will not be revised or included in the Cumulative Lists unless officially recommended.

Main Points

1. Proposed INNs and Their Details

Each proposed name includes:

Latin, English, French, Spanish translations.
Chemical name or description.
Action and use (e.g., antimalarial, antiviral, antineoplastic).
Molecular formula.
CAS registry number.
Graphic formula (image link).

2. Examples of Proposed INNs

Proposed INN (Latin/English)	French	Spanish	Chemical Name	Molecular Formula	CAS Registry Number
acideum salclobuzicum	acide salclobuzique	ácido salclobúzico	4-(4-chloro-2-hydroxybenzamido)butanoic acid pharmaceutical aid	$\mathrm{C_{11}H_{12}ClNO_4}$	387825-03-8
ancrivirocum	ancriviroc	ancriviroc	3-((4-[(Z)-(4-bromophenyl)(ethoxyimino)methyl]-4'-methyl[1,4'-bipiperidin]-1'-yl)carbonyl)-2,4-dimethylpyridine1-oxide antiviral	$\mathrm{C_{28}H_{37}BrN_4O_3}$	370893-06-4
artemifonum	artémifone	artemifona	(5R)-9-chloro-5-ethyl-5-hydroxy-10-methyl-12-[(4-methylpiperidin-1-yl)methyl]-1,4,5,13-tetrahydro-3H,15H-oxepino=[3',4':6,7]indolizino[1,2-b]quinoline-3,15-dione antineoplastic	$\mathrm{C_{19}H_{31}NO_6S}$	255730-18-8
atilmotinum	atilmotine	atilmotina	N-[(2S)-3-phenyl-2-(trimethylazaniumyl)propanoyl]-L-valyl-L-prolyl-L-isoleucyl-L-phenylalanyl-L-threonyl-L-tyrosylglycyl-L-glutamyl-L-leucyl-L-glutaminyl-D-arginyl-L-leucyl-L-lysinamide digestive agent	$\mathrm{C_{86}H_{134}N_{20}O_{19}}$	533927-56-9
avanafilum	avanafil	avanafilo	4-[[(3-chloro-4-methoxyphenyl)methyl]amino]-2-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]-N-(pyrimidin-2-ylmethyl)pyrimidine5-carboxamide vasodilator	$\mathrm{C_{23}H_{26}ClN_7O_3}$	330784-47-9
balicatum	balicatib	balicatib	N-1-([cyanomethyl)carbamoyl]cyclohexyl)-4-(4-propylpiperazin-1-yl)benzamide cathepsin K inhibitor	$\mathrm{C_{23}H_{33}N_5O_2}$	354813-19-7
becatecarinum	bécatécarine	becatecarina	1,11-dichloro-6-[2-(diethylamino)ethyl]-12-(4-O-methyl-β-D-glucopyranosyl)-12,13-dihydro-5H-indolo[2,3-a]pyrrolo=[3,4-c]carbazole-5,7(6H)-dione antineoplastic	$\mathrm{C_{33}H_{34}Cl_2N_4O_7}$	119673-08-4
bemotrizinolum	bemotrizinol	bemotrizinol	2,2'-[6-(4-methoxyphenyl)-1,3,5-triazine-2,4-diyl]bis={5-[(2-ethylhexyl)oxy]phenol} sunscreen	$\mathrm{C_{38}H_{49}N_3O_5}$	187393-00-6
bececalciolum	bécocalcidiol	becocalciidiol	(1R,3R)-4-(2-[(1R,3aS,7aR)-1-[(2S)-butan-2-yl]-7a-methyloctahydro-4H-inden-4-ylidene)ethylidene)-2-methyldencyclohexane-1,3-diol vitamin D analogue	$\mathrm{C_{23}H_{36}O_2}$	524067-21-8
delimitidum	delimitide	delimitida	2-deoxy-3-O-[(3R)-3-methoxydecyl]-6-O-methyl-2-(octadec-11-enamido)-4-O-phosphono- β-D-glucopyranosyl-(1 → 6)-3-O-decyl antineoplastic	$\mathrm{C_{66}H_{126}N_2O_{19}P_2}$	185955-34-4
farampatorum	farampator	farampator	5-[(piperidin-1-yl)carbonyl]-2,1,3-benzoxadiazole antipsychotic	$\mathrm{C_{12}H_{13}N_3O_2}$	211735-76-1
forodesinum	forodesine	forodesina	7-(5-amino-1,5-dideoxy- β-D-ribofuranos-1-yl)-1,5-dihydro 4H-pyrrolo[3,2-d]pyrimidin-4-one antineoplastic	$\mathrm{C_{11}H_{14}N_4O_4}$	209799-67-7
galsulfasum	galsulfase	galsulfasa	N-acetylgalactosamine 4-sulfatase (human CSL4S-342 cell) enzyme	$\mathrm{C_{2529}H_{3843}N_{689}O_{716}S_{16}}$	552858-79-4
iboctadekinum	iboctadekin	iboctadékine	A recombinant human interleukin-18 with 157 amino acids antineoplastic	$\mathrm{C_{801}H_{1264}N_{212}O_{252}S_{10}}$	479198-61-3
icomucretum	icomucret	icomucret	(5Z,8Z,11Z,13E,15S)-15-hydroxyicosa-5,8,11,13-tetraenoic acid mucin secretion stimulator	$\mathrm{C_{20}H_{32}O_3}$	54845-95-3
inotuzumab ozogamicin	inotuzumab ozogamicine	inotuzumab ozogamicina	Immunoglobulin G4, anti-(human CD22 (antigen)) (human-mouse monoclonal G544 heavy chain), disulfide with human-mouse monoclonal G544 κ-chain, dimer, conjugate with methyl N-{[(1R,4Z,8S,13E)-8-(4,6-dideoxy-4-[(4-S-[4-(6-deoxy-3-O-methyl-α-L-mannopyranosyl)oxy]-3-iodo-5,6-dimethoxy-2-methylbenzoyl)-4-thio-β-D-hexopyranosyl)oxy]amino}-2-O-[4-(N-ethylacetamido)-2,4-dideoxy-3-O-methyl-α-L-threo-pentopyranosyl)-β-D-glucopyranosyloxy)-13-[2-(4-[2-(1-(4-(4-amino-4-oxobutyl)oxy]phenyl)ethylidene)hydrazinyl)-2-methyl-4-oxobutan-2-yl]disulfanyl)ethylidene]-1-hydroxy-11-oxobicyclo[7.3.1]trideca-4,9-diene-2,6-diyn-10-yl]carbamate antineoplastic	$\mathrm{C_{2234}H_{3512}N_{650}O_{682}S_{10}}$	372075-36-0

Notes

Feedback Period: Comments or formal objections to proposed names can be submitted to the WHO INN Programme within four months of publication in WHO Drug Information.
Deadline for List 92: For List 92, the deadline was 16 May 2005.
Provisional Nature: The names listed are provisional and may not be included in the Cumulative Lists unless officially recommended.
Language Support: The names are provided in Latin, English, French, and Spanish to ensure international accessibility.
Chemical Descriptions: Each entry includes a detailed chemical name, molecular formula, CAS number, and graphic formula (image).
Function Classification: The substances are categorized by their pharmacological action (e.g., antipsychotic, antineoplastic, antiviral, etc.).