2021-09-01-世界卫生组织-INN_Recommended_List_86_147页_5mb

Summary of International Nonproprietary Names for Pharmaceutical Substances (INN) - List 86

Core Content

This document provides the Recommended International Nonproprietary Names (INN) for pharmaceutical substances, specifically focusing on List 86. It outlines the selected names, their chemical descriptions, molecular formulas, and additional information such as glycosylation sites and disulfide bridge positions. The names are presented in Latin, English, French, and Spanish, and the document emphasizes that the inclusion of a name in the Recommended INN list does not imply a recommendation for its medical use.

Main Points

• INN Selection Process: The names are selected in accordance with the Procedure for the Selection of Recommended INN, as outlined in WHO resolutions.
• List 86: Contains a variety of substances, including monoclonal antibodies and modified RNA molecules.
• Chemical Descriptions: Each substance includes its chemical name, molecular formula, and structural formula (graphic formula).
• Language Variations: The names are provided in multiple languages to ensure international understanding.
• Glycosylation and Disulfide Bridges: Information on N-glycosylation sites and disulfide bridge locations is included for each substance.
• Post-translational Modifications: Details about mutations and structural features are given for some substances.

Key Information

1. Abequolixronum

• INN: abequolixron
• Chemical Name: (3-((3R)-3-[[[2-chloro-3-(trifluoromethyl)phenyl]methyl]}2,2-diphenylethyl)amino]butoxy)phenyl)acetic acid
• Molecular Formula: $\mathrm{C_{34}H_{33}ClF_3NO_3}$
• Structure: Provided as an image.

2. Abrucomstatum

• INN: abrucomstat
• Chemical Name: 3-hydroxypropyl nitrate
• Molecular Formula: $\mathrm{C_3H_7NO_4}$
• Structure: Provided as an image.

3. Acasunlimabum

• INN: acasunlimab
• Chemical Description: Bispecific monoclonal antibody targeting CD274 and TNFRSF9
• Molecular Formula: $\mathrm{C_{34}H_{43}N_7O_{12}S_2}$
• Structure: Provided as an image.
• Post-translational Modifications:
  • Disulfide Bridges: Intra and inter chains (multiple positions listed).
  • Glycosylation Sites: N84, N119, N214.

4. Acidum Idroxioleicum

• INN: idroxioleic acid
• Chemical Name: rac-(2R,9Z)-2-hydroxyoctadec-9-enoic acid
• Molecular Formula: $\mathrm{C_{18}H_{34}O_3}$
• Structure: Provided as an image.

5. Adagrasibum

• INN: adagrasib
• Chemical Description: Complex molecule with a piperazin-2-ylacetonitrile core
• Molecular Formula: $\mathrm{C_{32}H_{35}ClF_2N_7O_2}$
• Structure: Provided as an image.
• Post-translational Modifications:
  • Disulfide Bridges: Intra and inter chains.
  • Glycosylation Sites: N84.4.

6. Adezmapimodum

• INN: adezmapimod
• Chemical Description: Pyridine derivative with imidazole and piperidine rings
• Molecular Formula: $\mathrm{C_{20}H_{25}N_5O_2}$
• Structure: Provided as an image.

7. Aficamtenum

• INN: aficamten
• Chemical Description: Carboxamide derivative with inden-1-yl and pyrazole groups
• Molecular Formula: $\mathrm{C_{18}H_{19}N_5O_2}$
• Structure: Provided as an image.

8. Afimetoranum

• INN: afimetorán
• Chemical Description: Piperidine derivative with indole and triazole rings
• Molecular Formula: $\mathrm{C_{20}H_{24}N_6O_2}$
• Structure: Provided as an image.

9. Alomfilimabum

• INN: alomfilimab
• Chemical Description: Bispecific monoclonal antibody targeting ICOS and TNFRSF9
• Molecular Formula: $\mathrm{C_{34}H_{43}N_7O_{12}S_2}$
• Structure: Provided as an image.
• Post-translational Modifications:
  • Disulfide Bridges: Intra and inter chains.
  • Glycosylation Sites: N84.4.

10. Amlitelimabum

• INN: amlitélimab
• Chemical Description: Monoclonal antibody targeting TNFSF4
• Molecular Formula: $\mathrm{C_{34}H_{43}N_7O_{12}S_2}$
• Structure: Provided as an image.
• Post-translational Modifications:
  • Disulfide Bridges: Intra and inter chains.
  • Glycosylation Sites: N84.4.

Additional Notes

• The Cumulative List No. 17, 2017 is referenced, containing both proposed and recommended INN.
• The post-translational modifications are detailed for several substances, including disulfide bridges and N-glycosylation sites.
• The structure of the substances is provided as images, which are not included in this summary due to formatting constraints.
• The production methods for some substances are noted, such as being produced in Chinese hamster ovary (CHO) cells.