2022-08-06-世界卫生组织-INN_Proposed_List_128_-COVID-_2页_222kb

Summary of WHO COVID-19 INN Proposal

• Document: WHO Drug Information, Volume 36, Issue 3, 2022 (special edition on COVID-19).
• Proposed INN List: List 128 – COVID-19 (special edition).
• Proposed Name: Secelasomeranum, designated as an mRNA vaccine for active immunization against SARS-CoV-2, targeting the Beta variant (B.1.351).
• Chemical Details: mRNA formulation includes 5'-capped sequence with codon optimization, two additional stop codons, N1-methylpseudouridine substitution, artificial 5' and 3' UTR derived from human HBA1 gene, and terminated with poly(A) tail.
• Comments Period: Closed on August 22, 2022, due to pandemic conditions reducing the usual four-month period to two weeks.
• Reference: Special procedure for variant COVID-19 vaccine active substances available at https://www.who.int/publications/i/item/inn-21-520.