2013-01-29-世界卫生组织-Public_Health_Research_Agenda_for_Influenza_-_Appendix_1_3页_48kb

WHO commissioned reviews, as outlined in Appendix 1, focus on various aspects of influenza research to inform public health decisions. The reviews cover virology, pandemic preparedness, economic impacts, vaccination, antiviral treatments, diagnostics, and modeling. Below is a summarized breakdown by the five streams:

• Stream 1: Examines virus-specific factors associated with zoonotic and pandemic potential, and highly pathogenic avian influenza, involving institutions like Istituto Zooprofilattico Sperimentale and Imperial College London. Publications include studies in PLoS ONE journals.

• Stream 2: Analyzes the role of host genetic factors in influenza susceptibility and draws lessons from school closures during the 2009 H1N1 outbreak, with contributions from Oxford University and Tohoku University. Research emphasizes literature reviews in PLoS ONE.

• Stream 3: Addresses economic costs of influenza, risk perception for vaccination, compliance with pharmaceutical measures, and assessments of antivirals and neuraminidase inhibitors. WHO and University of Edinburgh researchers contributed, with outputs in PLoS ONE and WHO bulletins.

• Stream 4: Focuses on influenza vaccination for vulnerable populations, such as immunocompromised patients and healthcare workers, as well as diagnostics and hospital care for severe cases. Reviews from McMaster University and WHO highlight evidence gaps and improvements in point-of-care testing.

• Stream 5: Involves mathematical modeling for pandemic decision-making, risk communication research, and mapping health communication networks during the 2009 H1N1 pandemic. Studies from the MRC Centre for Outbreak Analysis support public health strategies.

These reviews, published in collaborations with organizations like the WHO Collaborating Centre and universities, aim to enhance understanding and interventions for influenza across multiple domains.