2000-05-31-世界卫生组织-Guidelines_for_implementing_the_pre-eradication_phase_of_the_global_action_lan_for_laboratory_containment_of_wild_pilioviruses_41页_192kb

Summary of WHO Guidelines for Laboratory Inventory of Wild Poliovirus

Context and Purpose

• The guidelines address the need to manage and contain wild poliovirus infectious and/or potentially infectious materials (
  the risk of reintroduction into the community after global eradication efforts).
• The document is part of a larger action plan to ensure safety from laboratory sources of polioviruses.

Global Survey and Inventory System

• The Global Survey identifies laboratories retaining polioviruses by a hierarchical approach: starting from WHO, ministries of health, agencies/institutions, and then laboratories.
• This leads to a hierarchical inventory system:
  • Laboratory Inventory: Labs document wild poliovirus materials and BSL-2/polio safe handling.
  • Agency/Institution Inventory: Organizations compile inventory data and submit to the National Inventory.
  • National Inventory: Countries consolidate data from agencies/institutions and submit to WHO regional offices.
  • WHO Regional Inventory: Regional offices compile data for global inclusion.

Key Actions and Timelines

• All labs must search for poliovirus materials by their parent agency/institution and declare containment status.
• The inventory must be updated yearly and submitted by 2000 for regional certification.
• Trigger for containment: One year after the last wild poliovirus detection, WHO will request nations to initiate containment.

Definitions and Materials

• Specify infectious materials (e.g., clinical specimens, viral isolates) and potentially infectious materials (e.g., historical samples).
• Methods to handle identification and disposal are outlined, including conditions for maximum containment (BSL-3/polio for post-OPV period).

Requirements for Certification

• Completion of the National Inventory is required for polio-free certification at the regional and global levels.
• It serves to map current containment states and prioritize actions for containment.

The process involves collaboration across sectors to ensure comprehensive coverage and timely action for global polio eradication goals.