2010-12-08-世界卫生组织-INN_Proposed_List_104_68页_551kb

报告摘要

Summary of Proposed International Nonproprietary Names (INN) for Pharmaceutical Substances

Core Content

The document outlines the process and details of the World Health Organization's (WHO) proposed International Nonproprietary Names (INN) for pharmaceutical substances, specifically focusing on List 104. These names are used to identify substances in a standardized manner across international borders and are not a recommendation for medical use, but rather a designation for nomenclature purposes. The names are under consideration and are provisional, meaning they are not included in the Cumulative Lists of INNs unless finalized.

Key Information

INN Purpose: INNs are used to provide a common name for pharmaceutical substances, facilitating communication and understanding across different countries and languages.
Provisional Nature: The inclusion of a name in the Proposed INN list does not imply any recommendation for use. These names are subject to review and may be revised or rejected.
Feedback Mechanism: Any comments or formal objections to the proposed names must be submitted to the WHO INN Programme within four months of the publication date in WHO Drug Information.
List 104 Details: The proposed names are valid until 31 May 2011, with the publication date being 31 January 2011.

Main Points

1. Abediterolum / Abederol / Abéditerol / Abederol

Chemical Name: 5-[(1R)-2-{6-(2,2-difluoro-2-phenylethoxy)hexyl]amino}-1-hydroxyethyl]-8-hydroxyquinolin-2(1H)-one
Action/Use: β2-adrenoreceptor agonist
Molecular Formula: C25H30F2N2O4
CAS Registry Number: 915133-65-2

2. Adomiparinum Natricum / Adomiparin Sodium

Chemical Name: Sodium salt of a low molecular mass heparin obtained by enzymatic depolymerization of heparin from porcine intestinal mucosa
Action/Use: Anticoagulant
Molecular Formula: C25H30F2N2O4
CAS Registry Number: 9041-08-1

3. Aganepagum / Aganepag

Chemical Name: 5-{3-[(2S)-1-(4-[(1S)-1-hydroxyhexyl]phenyl)-5-oxopyrrolidin-2-yl]propyl}thiophene-2-carboxylic acid
Action/Use: Prostaglandin E2 receptor agonist
Molecular Formula: C24H31NO4S
CAS Registry Number: 910562-18-4

4. Alisertibum / Alisertib

Chemical Name: 4-{[9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino}-2-methoxybenzoic acid
Action/Use: Antineoplastic
Molecular Formula: C27H20ClFN4O4
CAS Registry Number: 1028486-01-2

5. Alvelestatum / Alvelestat

Chemical Name: N-{[5-(methanesulfonyl)pyridin-2-yl]methyl}-6-methyl-5-(1-methyl-1H-pyrazol-5-yl)-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2-dihydropyridine-3-carboxamide
Action/Use: Elastase inhibitor
Molecular Formula: C27H26F3N4O5
CAS Registry Number: 1174277-80-5

6. Amatuximabum / Amatuximab

Chemical Name: Immunoglobulin G1-kappa, anti-[Homo sapiens MSLN (mesothelin, pre-pro-megakaryocyte-potentiating factor, megakaryocyte-potentiating factor, MPF, CAK1)], chimeric monoclonal antibody
Action/Use: Antineoplastic
Molecular Formula: C25H22F3N5O4S
CAS Registry Number: 848141-11-7

7. Atinumabum / Atinumab

Chemical Name: Immunoglobulin G4-kappa, anti-[Homo sapiens RTN4 (reticulon 4, neurite outgrowth inhibitor, NOGO)], chimeric monoclonal antibody
Action/Use: Immunomodulator
Molecular Formula: C25H22F3N5O4S
CAS Registry Number: 1226761-65-4

8. Bisegliptinum / Bisegliptin

Chemical Name: Ethyl 4-{2-[(2S,4S)-2-cyano-4-fluoropyrrolidin-1-yl]-2-oxoethyl}amino)bicyclo[2.2.2]octane-1-carboxylate
Action/Use: Antidiabetic
Molecular Formula: C18H26FN3O3
CAS Registry Number: 862501-61-9

9. Burixaforum / Burixafor

Chemical Name: (2-{4-[6-amino-2-([(1r,4r)-4-((3-cyclohexylamino)propyl]amino)methyl)cyclohexylmethyl)amino)pyrimidin-4-yl]piperazin-1-yl)ethyl)phosphonic acid
Action/Use: Chemokine CXCR4 receptor antagonist
Molecular Formula: C27H51N8O3P
CAS Registry Number: 1191448-17-5

10. Cadazolidum / Cadazolid

Chemical Name: 1-cyclopropyl-6-fluoro-7-[4-(2-fluoro-4-[(5R)-5-(hydroxymethyl)-2-oxo-1,3-oxazolidin-3-yl]phenoxy)methyl)-4-hydroxypiperidin-1-yl]-4-oxo-1,4-dihydroquinolin-3-carboxylic acid
Action/Use: Antibacterial
Molecular Formula: C29H29F2N3O8
CAS Registry Number: 1025097-10-2

11. Carlumabum / Carlumab

Chemical Name: Immunoglobulin G1-kappa, anti-[Homo sapiens CCL2 (chemokine (C-C motif) ligand 2, C-C motif chemokine 2, monocyte chemoattractant protein-1, MCP-1, monocyte chemotactic and activating factor, MCAF, small inducible cytokine A2, SCYA2, HC11)], chimeric monoclonal antibody
Action/Use: Immunomodulator
Molecular Formula: C7108H11008N1968O2206S56
CAS Registry Number: 915404-94-3

12. Cenisertibum / Cenisertib

Chemical Name: (1S,2S,3R,4R)-3-[[5-fluoro-2-({3-methyl-4-(4-methylpiperazin-1-yl)phenyl}amino)pyrimidin-4-yl]amino]bicyclo[2.2.1]hept-5-ene-2-carboxamide
Action/Use: Antineoplastic
Molecular Formula: C24H30FN7O
CAS Registry Number: 871357-89-0

13. Crolibulinum / Crolibulin

Chemical Name: (4R)-2,7,8-triamino-4-(3-bromo-4,5-dimethoxyphenyl)-4H-chromene-3-carbonitrile
Action/Use: Antineoplastic
Molecular Formula: C18H17BrN4O3
CAS Registry Number: 1000852-17-4

14. Delamanidum / Delamanid

Chemical Name: (2R)-2-methyl-6-nitro-2-[(4-{4-[4-(trifluoromethoxy)phenoxy]piperidin-1-yl}phenoxy)methyl]-2,3-dihydroimidazo[2,1-b][1,3]oxazole
Action/Use: Antibacterial
Molecular Formula: C25H25F3N4O6
CAS Registry Number: 681492-22-8

Additional Notes

Feedback Period: Ends on 31 May 2011 for the proposed names in List 104.
Provisional Descriptors: These names are not to be revised or included in the Cumulative Lists unless finalized.
Language Support: The names are provided in Latin, English, French, and Spanish for international use.
Chemical Descriptions: Include molecular formulas, CAS numbers, and structural details for clarity.
Structural Information: Includes disulfide bridge positions and N-glycosylation sites for monoclonal antibodies.

This summary provides a concise overview of the proposed INNs, their chemical structures, potential uses, and the process for feedback.

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