2011-12-30-世界卫生组织-INN_names_for_radicals,_groups_others_Comprehensive_list_-_2012_80页_541kb

Summary of INN Document

Introduction

The document covers the World Health Organization's (WHO) International Nonproprietary Names (INN) Programme. It aims to assign unique, non-proprietary names to pharmaceutical substances for global identification and communication, ensuring safety and clarity in medicine use. The names are publicly available and used in pharmacopeias, product labeling, and scientific exchange.

Key Components

• INN Programme Overview: Established in the 1950s, it focuses on normative functions and has been integral to WHO's work for over 60 years. INNs are assigned to ensure distinct identification of substances, preventing confusion in prescription and dispensing.
• Selection Procedure: Proposed names are reviewed by an expert panel. A four-month comment period follows, after which a recommended INN is published if no objections are raised. Resolution WHA46.19 prohibits deriving trademarks from INNs to avoid confusion.
• Selection Criteria: Names must be distinctive, not overly long or confusing. Rules include avoiding certain letters (e.g., 'h', 'k') in favor of others (e.g., 'e' for 'ae', 'i' for 'y') to aid pronunciation in multiple languages. INN stems denote pharmacological groups.
• INN Stems and Names: Stems categorize drugs by pharmacological similarity. INNs for radicals and groups provide shortened names for inactive moieties, such as salts and esters, facilitating ease of use.
• Additional Details: The document outlines a comprehensive list of INN names, appendices for Greek letter transliteration, Spanish standardization of INN spellings, and specific rules for toxins, insulin qualifiers, and polyethylene glycol-based compounds. It emphasizes that INNs are not exhaustive and are continuously updated.

The document underscores the importance of INNs in standardizing global drug nomenclature for public health and safety.